UNIPAR has been coupled with the Comprehensive Air Quality Model with Extensions (CAMx) air quality model, which largely improved the prediction of SOA mass in three different regions: East Asia (KORUS-AQ in 2016); Central Valley, California (the National Chemical Speciation Monitoring Network in 2018 provided by the Bay Area Air Quality Management District [BAAQMD]), and the Southern U.S. (2022 Air Data from the U.S. EPA). The implement of heterogeneous chemistry in aqueous phase in CAMx=UNIAPR significantly improve the analysis of impacts of humidity and NOx levels on SOA formation.