{"id":93,"date":"2015-05-04T15:51:13","date_gmt":"2015-05-04T15:51:13","guid":{"rendered":"http:\/\/bme.ufl.edu\/labs\/stabler\/?page_id=93"},"modified":"2025-11-20T15:40:34","modified_gmt":"2025-11-20T19:40:34","slug":"oxysite-oxygen-generating-biomaterial","status":"publish","type":"page","link":"https:\/\/faculty.eng.ufl.edu\/stabler\/research\/engineering-site-for-islet-transplantation\/oxysite-oxygen-generating-biomaterial\/","title":{"rendered":"OxySite \u2013 Oxygen Generating Biomaterial"},"content":{"rendered":"\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2019\/05\/Oxysite-encapsulation-biomaterials.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"697\" height=\"164\" src=\"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2019\/05\/Oxysite-encapsulation-biomaterials.jpg\" alt=\"\" class=\"wp-image-1271\" srcset=\"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2019\/05\/Oxysite-encapsulation-biomaterials.jpg 697w, https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2019\/05\/Oxysite-encapsulation-biomaterials-300x71.jpg 300w\" sizes=\"auto, (max-width: 697px) 100vw, 697px\" \/><\/a><\/figure>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>While accelerating vascularization of the implant is highly desirable, there is always a hypoxic period between implantation and the development of a fully functional, intra-device vascular network. Limiting or eliminating this hypoxic period would dramatically reduce hypoxia-induced cell death and permit more clinically translatable devices, particularly for islets, which not only express high oxygen demand but are also sensitive to hypoxic stress. As such, we developed an in situ oxygen-generating biomaterial to provide supplemental oxygen immediately upon implantation, called <span style=\"text-decoration: underline\"><a href=\"http:\/\/patft.uspto.gov\/netacgi\/nph-Parser?Sect1=PTO1&amp;Sect2=HITOFF&amp;d=PALL&amp;p=1&amp;u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&amp;r=1&amp;f=G&amp;l=50&amp;s1=8986725.PN.&amp;OS=PN\/8986725&amp;RS=PN\/8986725\">OxySite<\/a><\/span>. Through manipulation of the material properties, we were able to develop a means to provide controlled and temporal oxygen to the microenvironment for extended time periods. We have published on the potential of this material to support islet viability <a href=\"https:\/\/www.pnas.org\/content\/109\/11\/4245.short\">in vitro<\/a> and <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961219302340\">in vivo<\/a><\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h6 class=\"wp-block-heading has-text-align-center\">Efforts in this area are currently being supported by the <a href=\"http:\/\/jdrf.org\/\"><u><span style=\"color: #0066cc\">JDRF <\/span><\/u><\/a><\/h6>\n\n\n\n<p class=\"has-text-align-center\">Press Releases by <a href=\"http:\/\/jdrf.org\/key-research-advances\/novel-oxygen-generating-biomaterials-developed-to-improve-islet-encapsulation\/\">JDRF<\/a> and <a href=\"http:\/\/med.miami.edu\/news\/dri-scientists-develop-oxygen-generating-biomaterial-to-improve-islet-survi\">UMiami <\/a><\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>While accelerating vascularization of the implant is highly desirable, there is always a hypoxic period between implantation and the development of a fully functional, intra-device vascular network. Limiting or eliminating this hypoxic period would dramatically reduce hypoxia-induced cell death and permit more clinically translatable devices, particularly for islets, which not only express high oxygen demand [&hellip;]<\/p>\n","protected":false},"author":468,"featured_media":0,"parent":87,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"page-templates\/page-section-nav.php","meta":{"_acf_changed":false,"inline_featured_image":false,"featured_post":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-93","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/93","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/users\/468"}],"replies":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/comments?post=93"}],"version-history":[{"count":2,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/93\/revisions"}],"predecessor-version":[{"id":5081,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/93\/revisions\/5081"}],"up":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/87"}],"wp:attachment":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/media?parent=93"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}