{"id":91,"date":"2015-05-04T15:49:38","date_gmt":"2015-05-04T15:49:38","guid":{"rendered":"http:\/\/bme.ufl.edu\/labs\/stabler\/?page_id=91"},"modified":"2025-11-20T15:38:00","modified_gmt":"2025-11-20T19:38:00","slug":"macro-porous-scaffolds","status":"publish","type":"page","link":"https:\/\/faculty.eng.ufl.edu\/stabler\/research\/engineering-site-for-islet-transplantation\/macro-porous-scaffolds\/","title":{"rendered":"Macro-porous Scaffolds"},"content":{"rendered":"\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"199\" height=\"300\" src=\"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2015\/05\/DRI_Labs066-low-199x300.jpg\" alt=\"\" class=\"wp-image-59\" srcset=\"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2015\/05\/DRI_Labs066-low-199x300.jpg 199w, https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2015\/05\/DRI_Labs066-low-680x1024.jpg 680w, https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2015\/05\/DRI_Labs066-low-768x1156.jpg 768w, https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2015\/05\/DRI_Labs066-low-1021x1536.jpg 1021w, https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2015\/05\/DRI_Labs066-low-1361x2048.jpg 1361w, https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2015\/05\/DRI_Labs066-low-scaled.jpg 1701w\" sizes=\"auto, (max-width: 199px) 100vw, 199px\" \/><\/figure>\n<\/div>\n\n\n<p>The use of macro-porous scaffolds, made from poly(dimethylsiloxane) (PDMS), is a platform developed in our laboratory to permit retrievability of the scaffold post-transplantation. We have explored the potential of these scaffolds within clinically relevant sites in pre-clinical models. Collectively, these results are promising in that they indicate the potential for transplanting islets into a clinically relevant, extrahepatic site that provides spatial distribution of islets, retrievability, and intra-device vascularization. We are now seeking to translate these promising results to the clinic. With the fabrication of a strong platform for housing cells, particularly islets, we then sought to explore how we may use this platform to interact and instruct the host response.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Our recent reviews on this topic:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41578-019-0112-5\">Engineering immunomodulatory biomaterials for type 1 diabetes<\/a>, published in&nbsp;<strong>Nature Reviews Materials<\/strong><\/li>\n\n\n\n<li><a class=\"gsc_vcd_title_link\" data-clk=\"hl=en&amp;sa=T&amp;ei=Gfn1X5XYEs6Ty9YPrrKhqAQ\" href=\"https:\/\/journals.lww.com\/transplantjournal\/Fulltext\/2016\/07000\/Executive_Summary_of_IPITA_TTS_Opinion_Leaders.31.aspx\">Executive summary of IPITA-TTS opinion leaders report on the future of \u03b2-cell replacement<\/a>, published in <strong>Transplantation<\/strong><\/li>\n\n\n\n<li><a class=\"gsc_vcd_title_link\" data-clk=\"hl=en&amp;sa=T&amp;ei=Nvn1X-nlAuCTy9YP9N2IkA0\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0958166913001183\">Engineering a local microenvironment for pancreatic islet replacement,<\/a> published in <strong>Current Opinion in Biotechnology<\/strong><\/li>\n<\/ul>\n\n\n\n<p>Learn more about scaffolds and the importance of selecting the appropriate implant site <a href=\"https:\/\/www.youtube.com\/watch?v=LSPWj7DSFOE\">here<\/a>.<\/p>\n\n\n\n<p>Learn more about scaffolds and the work we are doing to translate them to the clinic <a href=\"https:\/\/www.youtube.com\/watch?v=hL75f78O3nU\">here<\/a>.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h6 class=\"wp-block-heading has-text-align-center\">Efforts in this area are currently being supported by the <a href=\"http:\/\/jdrf.org\/\"><u><span style=\"color: #0066cc\">JDRF <\/span><\/u><\/a><\/h6>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The use of macro-porous scaffolds, made from poly(dimethylsiloxane) (PDMS), is a platform developed in our laboratory to permit retrievability of the scaffold post-transplantation. We have explored the potential of these scaffolds within clinically relevant sites in pre-clinical models. Collectively, these results are promising in that they indicate the potential for transplanting islets into a clinically [&hellip;]<\/p>\n","protected":false},"author":468,"featured_media":0,"parent":87,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"page-templates\/page-section-nav.php","meta":{"_acf_changed":false,"inline_featured_image":false,"featured_post":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-91","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/91","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/users\/468"}],"replies":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/comments?post=91"}],"version-history":[{"count":2,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/91\/revisions"}],"predecessor-version":[{"id":5079,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/91\/revisions\/5079"}],"up":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/87"}],"wp:attachment":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/media?parent=91"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}