{"id":422,"date":"2015-06-18T15:21:09","date_gmt":"2015-06-18T15:21:09","guid":{"rendered":"http:\/\/bme.ufl.edu\/labs\/stabler\/?page_id=422"},"modified":"2025-11-20T15:06:22","modified_gmt":"2025-11-20T19:06:22","slug":"diabetes-on-a-chip","status":"publish","type":"page","link":"https:\/\/faculty.eng.ufl.edu\/stabler\/research\/diabetes-on-a-chip\/","title":{"rendered":"Diabetes-on-a-Chip"},"content":{"rendered":"\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"407\" src=\"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2021\/01\/Diabetes-Chip-overview-e1609952196923.jpg\" alt=\"\" class=\"wp-image-1919\" srcset=\"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2021\/01\/Diabetes-Chip-overview-e1609952196923.jpg 400w, https:\/\/faculty.eng.ufl.edu\/stabler\/wp-content\/uploads\/sites\/497\/2021\/01\/Diabetes-Chip-overview-e1609952196923-295x300.jpg 295w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n<\/div>\n\n\n<p>Engineering organs for benchtop evaluation is a significant area of focus in the biomedical engineering community. The capacity to intimately characterize the influence of various parameters on organ function and viability, as well as its impact on &#8220;downstream&#8221; organs, would not only advance scientific knowledge but also minimize animal research and improve the safety and efficacy of potential new drugs. In the field of diabetes, a benchtop platform that supports islet function and viability long-term is a significant need, as current culturing techniques are unable to sustain islets longer than a few days. Our collaborative team has published on the development of such an &#8220;Islet-on-a-Chip&#8221;.<\/p>\n\n\n\n<p>Following the establishment of this platform, we are now transitioning to using this chip for the study of Type 1 Diabetes. Using induced pluripotent stem cells (iPSC), we can generate isogenic cell lines of beta cells, as well as the immune cell repertoire. The co-culture of these cells in a 3-D microfluidic chamber allows for tracking and examination of the islet-immune interface. <\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h6 class=\"wp-block-heading has-text-align-center\">The <a href=\"https:\/\/hirnetwork.org\/\">NIH Human Islet Research Network (HIRN)<\/a> supports our efforts in these areas via a <a href=\"https:\/\/projectreporter.nih.gov\/project_info_description.cfm?aid=9984339&amp;icde=53151316&amp;ddparam=&amp;ddvalue=&amp;ddsub=&amp;cr=2&amp;csb=default&amp;cs=ASC&amp;pball=\">UG3 grant<\/a><\/h6>\n","protected":false},"excerpt":{"rendered":"<p>Engineering organs for benchtop evaluation is a significant area of focus in the biomedical engineering community. The capacity to intimately characterize the influence of various parameters on organ function and viability, as well as its impact on &#8220;downstream&#8221; organs, would not only advance scientific knowledge but also minimize animal research and improve the safety and [&hellip;]<\/p>\n","protected":false},"author":468,"featured_media":0,"parent":84,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"page-templates\/page-section-nav.php","meta":{"_acf_changed":false,"inline_featured_image":false,"featured_post":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-422","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/422","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/users\/468"}],"replies":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/comments?post=422"}],"version-history":[{"count":5,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/422\/revisions"}],"predecessor-version":[{"id":5025,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/422\/revisions\/5025"}],"up":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/pages\/84"}],"wp:attachment":[{"href":"https:\/\/faculty.eng.ufl.edu\/stabler\/wp-json\/wp\/v2\/media?parent=422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}