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Publications and Patents

2025

2024

  • Lampejo, A. O., Lightsey, S. E., Gomes, M. C., Nguyen, C. M., Siemann, D. W., Sharma, B., & Murfee, W. L. (2024). A Novel Ex Vivo Tumor Spheroid-Tissue Model for Investigating Microvascular Remodeling and Lymphatic Blood Vessel Plasticity. Annals of Biomedical Engineering, 52(9), 2457–2472. https://doi.org/10.1007/s10439-024-03535-8

2023

  • Liang, C., Huang, M., Tanaka, M., Lightsey, S., Temples, M., Lepler, S. E., Sheng, P., Mann, W. P., Widener, A. E., Siemann, D. W., Sharma, B., Xie, M., Dai, Y., Phelps, E., Zeng, B., & Tang, X. (2023). Functional Interrogation of Ca2+ Signals in Human Cancer Cells In Vitro and Ex Vivo by Fluorescent Microscopy and Molecular Tools. In J. L. Garcia-Cordero & A. Revzin (Eds.), Microfluidic Systems for Cancer Diagnosis (pp. 95–125). Springer US. https://doi.org/10.1007/978-1-0716-3271-0_7
  • Ajayi, T. O., Liu, S., Rosen, C., Rinaldi-Ramos, C. M., Allen, K. D., & Sharma, B. (2023). Application of magnetic particle imaging to evaluate nanoparticle fate in rodent joints. Journal of Controlled Release, 356, 347–359. https://doi.org/10.1016/j.jconrel.2023.02.038
  • Aldrich, J. L., Panicker, A., Ovalle, R., & Sharma, B. (2023). Drug Delivery Strategies and Nanozyme Technologies to Overcome Limitations for Targeting Oxidative Stress in Osteoarthritis. Pharmaceuticals, 16(7), Article 7. https://doi.org/10.3390/ph16071044

2023

  • Liang, C., Huang, M., Tanaka, M., Lightsey, S., Temples, M., Lepler, S. E., Sheng, P., Mann, W. P., Widener, A. E., Siemann, D. W., Sharma, B., Xie, M., Dai, Y., Phelps, E., Zeng, B., & Tang, X. (2023). Functional Interrogation of Ca2+ Signals in Human Cancer Cells In Vitro and Ex Vivo by Fluorescent Microscopy and Molecular Tools. In J. L. Garcia-Cordero & A. Revzin (Eds.), Microfluidic Systems for Cancer Diagnosis (pp. 95–125). Springer US. https://doi.org/10.1007/978-1-0716-3271-0_7
  • Ajayi, T. O., Liu, S., Rosen, C., Rinaldi-Ramos, C. M., Allen, K. D., & Sharma, B. (2023). Application of magnetic particle imaging to evaluate nanoparticle fate in rodent joints. Journal of Controlled Release, 356, 347–359. https://doi.org/10.1016/j.jconrel.2023.02.038
  • Aldrich, J. L., Panicker, A., Ovalle, R., & Sharma, B. (2023). Drug Delivery Strategies and Nanozyme Technologies to Overcome Limitations for Targeting Oxidative Stress in Osteoarthritis. Pharmaceuticals, 16(7), Article 7. https://doi.org/10.3390/ph16071044

2022

  • Klopotowska, M., Bajor, M., Graczyk-Jarzynka, A., Kraft, A., Pilch, Z., Zhylko, A., Firczuk, M., Baranowska, I., Lazniewski, M., Plewczynski, D., Goral, A., Soroczynska, K., Domagala, J., Marhelava, K., Slusarczyk, A., Retecki, K., Ramji, K., Krawczyk, M., Temples, M. N., … Winiarska, M. (2022). PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress. Cancer Immunology Research, 10(2), 228–244. https://doi.org/10.1158/2326-6066.CIR-20-1023

2021

  • Sharma, B., Adjei, I., & Kumar, S. (2021). Composition and method for treating osteoarthritis with manganese dioxide nanoparticles (United States Patent US11179416B2). https://patents.google.com/patent/US11179416B2/en
  • Sharma, B., & Brown, S. B. (2021). Chondroprotective nanoparticles for the treatment of osteoarthritis (United States Patent US10993919B2). https://patents.google.com/patent/US10993919B2/en
  • Lanier, O. L., Ficarrotta, J. M., Adjei, I., Wable, D., Lewis, C., Nacea, C., Sharma, B., Dobson, J., & McFetridge, P. (2021). Magnetically Responsive Polymeric Microparticles for the Triggered Delivery of a Complex Mixture of Human Placental Proteins. Macromolecular Bioscience, 21(1), 2000249. https://doi.org/10.1002/mabi.202000249
  • Arias, J., Scott, K. W., Zaldivar, J. R., Trumbull, D. A., Sharma, B., Allen, K., & Gravenstein, N. (n.d.). Innovation-Oriented Medical School Curricula: Review of the Literature. Cureus, 13(10), e18498. https://doi.org/10.7759/cureus.18498

2020

  • Temples, M. N., & Sharma, B. (2020). Manufacturing of natural killer cells for treating solid malignancies. Journal of Immunology and Regenerative Medicine, 10, 100031. https://doi.org/10.1016/j.regen.2020.100031
  • Wolf, M. T., Zhang, H., Sharma, B., Marcus, N. A., Pietzner, U., Fickert, S., Lueth, A., Albers, G. H. R., & Elisseeff, J. H. (2020). Two-Year Follow-Up and Remodeling Kinetics of ChonDux Hydrogel for Full-Thickness Cartilage Defect Repair in the Knee. CARTILAGE, 11(4), 447–457. https://doi.org/10.1177/1947603518800547
  • Brown, S. B., Hornyak, J. A., Jungels, R. R., Shah, Y. Y., Yarmola, E. G., Allen, K. D., & Sharma, B. (2020). Characterization of Post-Traumatic Osteoarthritis in Rats Following Anterior Cruciate Ligament Rupture by Non-Invasive Knee Injury (NIKI). Journal of Orthopaedic Research, 38(2), 356–367. https://doi.org/10.1002/jor.24470
  • Adjei, I., & Sharma, B. (2020). Composition and method for targeting natural killer cells in immunotherapy to overcome tumor suppression with manganese dioxide nanoparticles (United States Patent US20200390807A1). https://patents.google.com/patent/US20200390807A1/en
  • Temples, M. N., Adjei, I. M., Nimocks, P. M., Djeu, J., & Sharma, B. (2020). Engineered Three-Dimensional Tumor Models to Study Natural Killer Cell Suppression. ACS Biomaterials Science & Engineering, 6(7), 4179–4199. https://doi.org/10.1021/acsbiomaterials.0c00259
  • Kumar, S., & Sharma, B. (2020). Leveraging Electrostatic Interactions for Drug Delivery to the Joint. Bioelectricity, 2(2), 82–100. https://doi.org/10.1089/bioe.2020.0014

2019

  • Adjei, I. M., Jordan, J., Tu, N., Trinh, T. L., Kandell, W., Wei, S., & Sharma, B. (2019). Functional recovery of natural killer cell activity by nanoparticle-mediated delivery of transforming growth factor beta 2 small interfering RNA. Journal of Interdisciplinary Nanomedicine, 4(4), 98–112. https://doi.org/10.1002/jin2.63
  • Brown, S., Kumar, S., & Sharma, B. (2019). Intra-articular targeting of nanomaterials for the treatment of osteoarthritis. Acta Biomaterialia, 93, 239–257. https://doi.org/10.1016/j.actbio.2019.03.010
  • Brown, S., Pistiner, J., Adjei, I. M., & Sharma, B. (2019). Nanoparticle Properties for Delivery to Cartilage: The Implications of Disease State, Synovial Fluid, and Off-Target Uptake. Molecular Pharmaceutics, 16(2), 469–479. https://doi.org/10.1021/acs.molpharmaceut.7b00484
  • Kumar, S., Adjei, I. M., Brown, S. B., Liseth, O., & Sharma, B. (2019). Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress. Biomaterials, 224, 119467. https://doi.org/10.1016/j.biomaterials.2019.119467
  • Adjei, I. M., Yang, H., Plumton, G., Maldonado-Camargo, L., Dobson, J., Rinaldi, C., Jiang, H., & Sharma, B. (2019). Multifunctional nanoparticles for intracellular drug delivery and photoacoustic imaging of mesenchymal stem cells. Drug Delivery and Translational Research, 9(3), 652–666. https://doi.org/10.1007/s13346-019-00621-6

2018

  • Martin-Pena, A., Porter, R. M., Plumton, G., McCarrel, T. M., Morton, A. J., Guijarro, M. V., Ghivizzani, S. C., Sharma, B., & Palmer, G. D. (2018). Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations. European Cells & Materials, 36, 156–170. https://doi.org/10.22203/eCM.v036a12
  • Adjei, I. M., Temples, M. N., Brown, S. B., & Sharma, B. (2018). Targeted Nanomedicine to Treat Bone Metastasis. Pharmaceutics, 10(4), Article 4. https://doi.org/10.3390/pharmaceutics10040205

2016

  • Adjei, I. M., Plumton, G., & Sharma, B. (2016). Chapter Four – Oxidative Stress and Biomaterials: The Inflammatory Link. In T. Dziubla & D. A. Butterfield (Eds.), Oxidative Stress and Biomaterials (pp. 89–115). Academic Press. https://doi.org/10.1016/B978-0-12-803269-5.00004-8
  • Adjei, I. M., Sharma, B., Peetla, C., & Labhasetwar, V. (2016). Inhibition of bone loss with surface-modulated, drug-loaded nanoparticles in an intraosseous model of prostate cancer. Journal of Controlled Release, 232, 83–92. https://doi.org/10.1016/j.jconrel.2016.04.019
  • Sharma, B., & Varghese, S. (2016). Progress in orthopedic biomaterials and drug delivery. Drug Delivery and Translational Research, 6(2), 75–76. https://doi.org/10.1007/s13346-016-0288-9
  • Sridharan, B., Sharma, B., & Detamore, M. S. (2016). A Road Map to Commercialization of Cartilage Therapy in the United States of America. Tissue Engineering Part B: Reviews, 22(1), 15–33. https://doi.org/10.1089/ten.teb.2015.0147
  • Tonello, S., Moore, M. C., Sharma, B., Dobson, J., & McFetridge, P. S. (2016). Controlled release of a heterogeneous human placental matrix from PLGA microparticles to modulate angiogenesis. Drug Delivery and Translational Research, 6(2), 174–183. https://doi.org/10.1007/s13346-016-0281-3

2000-2015

  • Adjei, I. M., & Blanka, S. (2015). Modulation of the Tumor Microenvironment for Cancer Treatment: A Biomaterials Approach. Journal of Functional Biomaterials, 6(1), Article 1. https://doi.org/10.3390/jfb6010081
  • Adjei, I. M., Sharma, B., & Labhasetwar, V. (2014). Nanoparticles: Cellular Uptake and Cytotoxicity. In D. G. Capco & Y. Chen (Eds.), Nanomaterial: Impacts on Cell Biology and Medicine (pp. 73–91). Springer Netherlands. https://doi.org/10.1007/978-94-017-8739-0_5
  • Sharma, B., Fermanian, S., Gibson, M., Unterman, S., Herzka, D. A., Cascio, B., Coburn, J., Hui, A. Y., Marcus, N., Gold, G. E., & Elisseeff, J. H. (2013). Human Cartilage Repair with a Photoreactive Adhesive-Hydrogel Composite. Science Translational Medicine, 5(167), 167ra6-167ra6. https://doi.org/10.1126/scitranslmed.3004838
  • Sharma, B., Peetla, C., Adjei, I. M., & Labhasetwar, V. (2013). Selective biophysical interactions of surface modified nanoparticles with cancer cell lipids improve tumor targeting and gene therapy. Cancer Letters, 334(2), 228–236. https://doi.org/10.1016/j.canlet.2013.03.011
  • Shaina, S., Mahajan, S., Chandra, R., & Sharma, B. P. (2012). Evaluation of Results of Operative Treatment of Displaced Fractures of Metacarpals. Journal of Bone and Joint Diseases, 27(1), 34.
  • Prabha, S., Sharma, B., & Labhasetwar, V. (2012). Inhibition of tumor angiogenesis and growth by nanoparticle-mediated p53 gene therapy in mice. Cancer Gene Therapy, 19(8), 530–537. https://doi.org/10.1038/cgt.2012.26
  • Sharma, B., Ma, W., Adjei, I. M., Panyam, J., Dimitrijevic, S., & Labhasetwar, V. (2011). Nanoparticle-mediated p53 gene therapy for tumor inhibition. Drug Delivery and Translational Research, 1(1), 43–52. https://doi.org/10.1007/s13346-010-0008-9
  • Manthe, R. L., Foy, S. P., Krishnamurthy, N., Sharma, B., & Labhasetwar, V. (2010). Tumor Ablation and Nanotechnology. Molecular Pharmaceutics, 7(6), 1880–1898. https://doi.org/10.1021/mp1001944
  • Cascio, B. M., & Sharma, B. (2008). The Future of Cartilage Repair. Operative Techniques in Sports Medicine, 16(4), 221–224. https://doi.org/10.1053/j.otsm.2009.01.001
  • Ramaswamy, S., Gurkan, I., Sharma, B., Cascio, B., Fishbein, K. W., & Spencer, R. G. (2008). Assessment of tissue repair in full thickness chondral defects in the rabbit using magnetic resonance imaging transverse relaxation measurements. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 86B(2), 375–380. https://doi.org/10.1002/jbm.b.31030
  • Hwang, N. S., Varghese, S., Lee, H. J., Theprungsirikul, P., Canver, A., Sharma, B., & Elisseeff, J. (2007). Response of zonal chondrocytes to extracellular matrix-hydrogels. FEBS Letters, 581(22), 4172–4178. https://doi.org/10.1016/j.febslet.2007.07.049
  • Sharma, B. (2006). Engineering stratified tissues for in situ cartilage regeneration [Ph.D., The Johns Hopkins University]. https://www.proquest.com/docview/305319238/abstract/761200CD9B8D4F55PQ/1
  • Sharma, B., Williams, C. G., Khan, M., Manson, P., & Elisseeff, J. H. (2007). In Vivo Chondrogenesis of Mesenchymal Stem Cells in a Photopolymerized Hydrogel. Plastic and Reconstructive Surgery, 119(1), 112. https://doi.org/10.1097/01.prs.0000236896.22479.52
  • Wang, D.-A., Varghese, S., Sharma, B., Strehin, I., Fermanian, S., Gorham, J., Fairbrother, D. H., Cascio, B., & Elisseeff, J. H. (2007). Multifunctional chondroitin sulphate for cartilage tissue–biomaterial integration. Nature Materials, 6(5), 385–392.
  • Sharma, B., Williams, C. G., Kim, T. K., Sun, D., Malik, A., Khan, M., Leong, K., & Elisseeff, J. H. (2007). Designing Zonal Organization into Tissue-Engineered Cartilage. Tissue Engineering, 13(2), 405–414. https://doi.org/10.1089/ten.2006.0068
  • Li, Q., Wang, J., Shahani, S., Sun, D. D. N., Sharma, B., Elisseeff, J. H., & Leong, K. W. (2006). Biodegradable and photocrosslinkable polyphosphoester hydrogel. Biomaterials, 27(7), 1027–1034. https://doi.org/10.1016/j.biomaterials.2005.07.019
  • Elisseeff, J., Puleo, C., Yang, F., & Sharma, B. (2005). Advances in skeletal tissue engineering with hydrogels. Orthodontics & Craniofacial Research, 8(3), 150–161. https://doi.org/10.1111/j.1601-6343.2005.00335.x
  • Williams, C., Sharma, B., & Elisseeff, J. (2005). Multi-layered polymerizing hydrogels for tissue regeneration (United States Patent US20050069572A1). https://patents.google.com/patent/US20050069572A1/en
  • Alhadlaq, A., Elisseeff, J. H., Hong, L., Williams, C. G., Caplan, A. I., Sharma, B., Kopher, R. A., Tomkoria, S., Lennon, D. P., Lopez, A., & Mao, J. J. (2004). Adult Stem Cell Driven Genesis of Human-Shaped Articular Condyle. Annals of Biomedical Engineering, 32(7), 911–923. https://doi.org/10.1023/B:ABME.0000032454.53116.ee
  • Sharma, B., & Elisseeff, J. H. (2004). Engineering Structurally Organized Cartilage and Bone Tissues. Annals of Biomedical Engineering, 32(1), 148–159. https://doi.org/10.1023/B:ABME.0000007799.60142.78
  • Kim, T.-K., Sharma, B., Williams, C. G., Ruffner, M. A., Malik, A., McFarland, E. G., & Elisseeff, J. H. (2003). Experimental Model for Cartilage Tissue Engineering to Regenerate the Zonal Organization of Articular Cartilage. Osteoarthritis and Cartilage, 11(9), 653–664. https://doi.org/10.1016/S1063-4584(03)00120-1