{"id":654,"date":"2019-09-29T18:59:41","date_gmt":"2019-09-29T18:59:41","guid":{"rendered":"https:\/\/www.che.ufl.edu\/rinaldi\/?p=654"},"modified":"2019-09-29T18:59:41","modified_gmt":"2019-09-29T18:59:41","slug":"nanoparticle-dynamics","status":"publish","type":"post","link":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/2019\/09\/29\/nanoparticle-dynamics\/","title":{"rendered":"Magnetic Nanoparticle Dynamics in Time-Varying Magnetic Fields"},"content":{"rendered":"\n<p>The response of biocompatible magnetic nanoparticles to time-varying magnetic fields forms the basis of exciting biomedical applications, such as nanoscale magnetic thermal therapy (magnetic hyperthermia), magnetic particle imaging, relaxometric sensing, and magnetically-triggered drug release. In all these applications, understanding the coupling between magnetic, hydrodynamic, thermal, and magnetocrystalline torques on the magnetic nanoparticle dipoles is vital to predict the performance of magnetic nanoparticles. Our group has made fundamental contributions to understanding these phenomena through a combination of theoretical, simulation, and experimental approaches. Modeling of rotational Brownian relaxation and internal dipole rotation in the nanoparticles has led to understanding of the effect of non-linear magnetization on heat dissipation rates and understanding of the role of relaxation time and relaxation mechanism on magnetic particle imaging signal strength and resolution. This understanding is enabling realization of the theranostic potential of magnetic nanoparticles in magnetic particle imaging and hyperthermia applications.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Related Publications:<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Zhiyuan Zhao<sup>G<\/sup> and <strong>Carlos Rinaldi<\/strong>, \u201cComputational predictions of enhanced magnetic particle imaging performance by magnetic nanoparticle chains.\u201d <em>Physics in Medicine and Biology<\/em>, <strong>65<\/strong>:185013, 2020. [<a href=\"https:\/\/doi.org\/10.1088\/1361-6560\/ab95dd\">https:\/\/doi.org\/10.1088\/1361-6560\/ab95dd<\/a>]<\/li>\n<li>Zhiyuan Zhao<sup>G<\/sup>, Nicolas Garraud, David Arnold, and <strong>Carlos Rinaldi<\/strong>, \u201cEffects of particle diameter and magnetocrystalline anisotropy on magnetic relaxation and magnetic particle imaging performance of magnetic nanoparticles.\u201d <em>Physics in Medicine and Biology<\/em>, <strong>65<\/strong>(2):025014, 2020. [<a href=\"https:\/\/doi.org\/10.1088\/1361-6560\/ab5b83\">https:\/\/doi.org\/10.1088\/1361-6560\/ab5b83<\/a>]<\/li>\n<li>Nicolas Garraud, Rohan Dhavalikar<sup>G<\/sup>, Mythreyi Unni<sup>G<\/sup>, Shehaab Savliwala<sup>G<\/sup>, David P. Arnold, and <strong>Carlos Rinaldi<\/strong>, \u201cBenchtop magnetic particle relaxometer for detection, characterization, and analysis of magnetic nanoparticles.\u201d <em>Physics in Medicine and Biology<\/em>, <strong>63<\/strong>:175016, 2018. [<a href=\"http:\/\/doi.org\/10.1088\/1361-6560\/aad97d\">http:\/\/doi.org\/10.1088\/1361-6560\/aad97d<\/a>]<\/li>\n<li>Zhiyuan Zhao<sup>G<\/sup> and <strong>Carlos Rinaldi<\/strong>, \u201cMagnetization dynamics and energy dissipation of interacting magnetic nanoparticles in alternating magnetic fields with and without a static bias field.\u201d <em>The Journal of Physical Chemistry C<\/em>, <strong>122<\/strong>(36):21018-21030, 2018. [<a href=\"http:\/\/doi.org\/10.1021\/acs.jpcc.8b04071\">http:\/\/doi.org\/10.1021\/acs.jpcc.8b04071<\/a>]<\/li>\n<li>Nicolas Garraud, Rohan Dhavalikar<sup>G<\/sup>, Lorena Maldonado-Camargo<sup>G<\/sup>, David P. Arnold, and <strong>Carlos Rinaldi<\/strong>, \u201cDesign and Validation of Magnetic Particle Spectrometer for Characterization of Magnetic Nanoparticle Relaxation Dynamics.\u201d <em>AIP Advances<\/em>, <strong>7<\/strong>:056730, 2017. [<a href=\"http:\/\/doi.org\/10.1063\/1.4978003\">http:\/\/doi.org\/10.1063\/1.4978003<\/a>]<\/li>\n<li>Zhiyuan Zhao<sup>G<\/sup>, Isaac Torres-D\u00edaz<sup>P<\/sup>, Camilo Velez, David Arnold, and <strong>Carlos Rinaldi<\/strong>, \u201cBrownian Dynamics Simulations of Magnetic Nanoparticles in Strong Magnetic Field Gradients.\u201d <em>The Journal of Physical Chemistry C<\/em>, <strong>121<\/strong>(1):801-810, 2017. [<a href=\"http:\/\/doi.org\/10.1021\/acs.jpcc.6b09409\">http:\/\/doi.org\/10.1021\/acs.jpcc.6b09409<\/a>]<\/li>\n<li>Rohan Dhavalikar<sup>G<\/sup> and <strong>Carlos Rinaldi<\/strong>, \u201cTheoretical Predictions for the Spatial Distribution of Magnetic Nanoparticle Heating in Magnetic Particle Imaging Field Gradients.\u201d <em>Journal of Magnetism and Magnetic Materials<\/em>, <strong>419<\/strong>:267-273, 2016. [<a href=\"http:\/\/doi.org\/10.1016\/j.jmmm.2016.06.038\">http:\/\/doi.org\/10.1016\/j.jmmm.2016.06.038<\/a>]<\/li>\n<li>Lorena P. Maldonado-Camargo<sup>G<\/sup>, Isaac Torres-D\u00edaz<sup>P<\/sup>, Maria E. Hern\u00e1ndez, and <strong>Carlos Rinaldi<\/strong>, \u201cEstimating the contribution of Brownian and N\u00e9el relaxation in a magnetic fluid through dynamic magnetic susceptibility measurements.\u201d <em>Journal of Magnetism and Magnetic Materials<\/em>, <strong>412<\/strong>:223-233,2016. [<a href=\"http:\/\/doi.org\/10.1016\/j.jmmm.2016.03.087\">http:\/\/doi.org\/10.1016\/j.jmmm.2016.03.087<\/a>]<\/li>\n<li>Rohan Dhavalikar<sup>G<\/sup>, Lorena P. Maldonado-Camargo<sup>G<\/sup>, Daniel Hensley, Patrick S. Goodwill, Steven M. Conolly, and <strong>Carlos Rinaldi<\/strong>, \u201cFinite magnetic relaxation in X-Space magnetic particle imaging: Comparison of measurements and ferrohydrodynamic modeling.\u201d <em>Journal of Physics D<\/em>, <strong>49<\/strong>(30):305002, 2016. [<a href=\"http:\/\/doi.org\/10.1088\/0022-3727\/49\/30\/305002\">http:\/\/doi.org\/10.1088\/0022-3727\/49\/30\/305002<\/a>]<\/li>\n<li>Rohan Dhavalikar<sup>G<\/sup>, Nicolas Garraud, and <strong>Carlos Rinaldi<\/strong>, \u201cFerrohydrodynamic modeling of magnetic nanoparticle harmonic spectra for magnetic particle imaging.\u201d <em>Journal of Applied Physics<\/em>, <strong>118<\/strong>:173906, 2015. [<a href=\"http:\/\/doi.org\/10.1063\/1.4935158\">http:\/\/doi.org\/10.1063\/1.4935158<\/a>, PMID: 26576063]<\/li>\n<li>Denisse Soto-Aquino<sup>G<\/sup> and <strong>Carlos Rinaldi<\/strong>, \u201cNonlinear energy dissipation in magnetic nanoparticle suspensions,\u201d <em>Journal of Magnetism and Magnetic Materials<\/em>, <strong>393<\/strong>:46-55,2015. [<a href=\"http:\/\/doi.org\/10.1016\/j.jmmm.2015.05.009\">http:\/\/doi.org\/10.1016\/j.jmmm.2015.05.009<\/a>]<\/li>\n<li>Isaac Torres-D\u00edaz<sup>P<\/sup> and <strong>Carlos Rinaldi<\/strong>, \u201cBrownian dynamics simulations of magnetizable ellipsoidal particle suspensions.\u201d <em>Journal of Physics D: Applied Physics<\/em>, <strong>47<\/strong>:235003,2014. [<a href=\"http:\/\/doi.org\/10.1088\/0022-3727\/47\/23\/235003\">http:\/\/doi.org\/10.1088\/0022-3727\/47\/23\/235003<\/a>]<\/li>\n<li>Rohan Dhavalikar<sup>G<\/sup> and <strong>Carlos Rinaldi<\/strong>, \u201cOn the effect of finite magnetic relaxation on the magnetic particle imaging performance of magnetic nanoparticles.\u201d <em>Journal of Applied Physics<\/em>, <strong>115<\/strong>:074308,2014. [<a href=\"http:\/\/doi.org\/10.1063\/1.4866680\">http:\/\/doi.org\/10.1063\/1.4866680<\/a>]<\/li>\n<li>Jorge H. S\u00e1nchez<sup>G<\/sup>, and <strong>Carlos Rinaldi<\/strong>, \u201cRotational Brownian dynamics simulations of suspensions of non-interacting magnetic ellipsoidal particles in d.c. and a.c. magnetic fields.\u201d <em>Journal of Magnetism and Magnetic Materials<\/em>, <strong>321<\/strong>(19): 2985-2991, October 2009. [<a href=\"http:\/\/doi.org\/10.1016\/j.jmmm.2009.04.066\">http:\/\/doi.org\/10.1016\/j.jmmm.2009.04.066<\/a>]<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>The response of biocompatible magnetic nanoparticles to time-varying magnetic fields forms the basis of exciting biomedical applications, such as nanoscale magnetic thermal therapy (magnetic hyperthermia), magnetic particle imaging, relaxometric sensing, and magnetically-triggered drug release. In all these applications, understanding the coupling between magnetic, hydrodynamic, thermal, and magnetocrystalline torques on the magnetic nanoparticle dipoles is vital [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":388,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"featured_post":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[5,9],"tags":[],"class_list":["post-654","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-contributions","category-homepage-slider"],"acf":[],"_links":{"self":[{"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/posts\/654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/comments?post=654"}],"version-history":[{"count":0,"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/posts\/654\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/media\/388"}],"wp:attachment":[{"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/media?parent=654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/categories?post=654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/tags?post=654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}