{"id":1339,"date":"2025-02-20T13:43:01","date_gmt":"2025-02-20T18:43:01","guid":{"rendered":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/?page_id=1339"},"modified":"2025-02-20T13:43:01","modified_gmt":"2025-02-20T18:43:01","slug":"magnetic-particle-imaging","status":"publish","type":"page","link":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/research\/magnetic-particle-imaging\/","title":{"rendered":"Magnetic Particle Imaging"},"content":{"rendered":"\n<p>Magnetic particle imaging (MPI) is an emerging molecular imaging modality that enables non-invasive, tomographic, unambiguous, sensitive, and quantitative imaging of the distribution of superparamagnetic iron oxide nanoparticles (SPIONs) in a living subject. MPI signal is not attenuated by tissue and arises solely from exogenous SPIONs that are biocompatible and biodegradable. While MPI is relatively new, rapid progress towards clinical translation is taking place and there much excitement over applications in blood pool imaging, molecular imaging of disease markers, and quantitative tracking of nanomedicines and cell therapies. Rinaldi-Ramos\u2019s lab is making fundamental contributions to understanding the role of SPION relaxation mechanisms and interactions on their MPI performance. In collaboration with Steve Conolly, one of the pioneers of the field of MPI, Rinaldi-Ramos\u2019s lab has demonstrated MPI guided and spatially controlled hyperthermia using SPIONs. Furthermore, Rinaldi-Ramos\u2019s lab has developed new SPION synthesis techniques that yield nearly defect free nanoparticles with enhanced MPI performance. These unique SPIONs are being formulated for applications in drug delivery, cell tracking, and organ cryopreservation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Related Publications<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Andreina Chiu Lam<sup>G<\/sup>, Edward Staples, Carl Pepine, and <strong>Carlos Rinaldi<\/strong>, \u201cPerfusion, cryopreservation, and nanowarming of whole hearts using colloidally stable cryopreservation agent solutions.\u201d <em>Science Advances, <\/em><strong>7<\/strong>(2):eabe3005, 2021. [<a href=\"https:\/\/doi.org\/10.1126\/sciadv.abe3005\">https:\/\/doi.org\/10.1126\/sciadv.abe3005<\/a>]<\/li>\n\n\n\n<li>Yao Lu, Angelie Rivera-Rodriguez<sup>G<\/sup>, Zhi Wei Tay, Daniel Hensley, K.L. Barry Fung, Caylin Colson, Chinmoy Saayujya, Quincy Huynh, Leyla Kabuli, Benjamin Fellows, Prashant Chandrasekharan, <strong>Carlos Rinaldi<\/strong>, and Steven Conolly, \u201cCombining magnetic particle imaging and magnetic hyperthermia for localized and image-guided treatment.\u201d <em>International Journal of Hyperthermia<\/em>, <strong>37<\/strong>(3):141-154, 2020. [<a href=\"https:\/\/doi.org\/10.1080\/02656736.2020.1853252\">https:\/\/doi.org\/10.1080\/02656736.2020.1853252<\/a>]<\/li>\n\n\n\n<li>Zhiyuan Zhao<sup>G<\/sup> and <strong>Carlos Rinaldi<\/strong>, \u201cComputational predictions of enhanced magnetic particle imaging performance by magnetic nanoparticle chains.\u201d <em>Physics in Medicine and Biology<\/em>, <strong>65<\/strong>:185013, 2020. [<a href=\"https:\/\/doi.org\/10.1088\/1361-6560\/ab95dd\">https:\/\/doi.org\/10.1088\/1361-6560\/ab95dd<\/a>]<\/li>\n\n\n\n<li>Nathanne C.V. Rost<sup>F<\/sup>, Kacoli Sen<sup>P<\/sup>, Ishita Singh<sup>G<\/sup>, Leando Raniero, and <strong>Carlos Rinaldi<\/strong>, \u201cMagnetic particle imaging performance of liposomes encapsulating iron oxide nanoparticles.\u201d <em>Journal of Magnetism and Magnetic Materials<\/em>, <strong>504<\/strong>:166675, 2020. [<a href=\"https:\/\/doi.org\/10.1016\/j.jmmm.2020.166675\">https:\/\/doi.org\/10.1016\/j.jmmm.2020.166675<\/a>]<\/li>\n\n\n\n<li>Zhiyuan Zhao<sup>G<\/sup>, Nicolas Garraud, David Arnold, and <strong>Carlos Rinaldi<\/strong>, \u201cEffects of particle diameter and magnetocrystalline anisotropy on magnetic relaxation and magnetic particle imaging performance of magnetic nanoparticles.\u201d <em>Physics in Medicine and Biology<\/em>, <strong>65<\/strong>(2):025014, 2020. [<a href=\"https:\/\/doi.org\/10.1088\/1361-6560\/ab5b83\">https:\/\/doi.org\/10.1088\/1361-6560\/ab5b83<\/a>]<\/li>\n\n\n\n<li>Prashant Chandrasekharan, Zhi Wei Tay, Daniel Hensley, Xinyi Y Zhou, Barry KL Fung, Caylin Colson, Yao Lu, Benjamin D Fellows, Quincy Huynh, Chinmoy Saayujya, Elaine Yu, Ryan Orendorff, Zheng Bo, Patrick Goodwill, <strong>Carlos Rinaldi<\/strong>, and Steven Conolly, \u201cUsing magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: Tracers, hardware, and future medical applications.\u201d <em>Theranostics<\/em>, 10(7):2965, 2020. [<a href=\"https:\/\/doi.org\/10.7150\/thno.40858\">https:\/\/doi.org\/10.7150\/thno.40858<\/a>]<\/li>\n\n\n\n<li>Eric Fuller<sup>*G<\/sup>, Georg M. Scheutz<sup>*<\/sup>, Angela Jimenez<sup>U<\/sup>, Parker Lewis<sup>U<\/sup>, Shehaab Savliwala<sup>G<\/sup>, Sitong Liu<sup>G<\/sup>, Brent S. Sumerlin, and <strong><u>Carlos Rinaldi<\/u><\/strong>, \u201cTheranostic nanocarriers combining high drug loading and magnetic particle imaging.\u201d <em>International Journal of Pharmaceutics<\/em>, <strong>572<\/strong>, 118796, 2019. [<a href=\"https:\/\/doi.org\/10.1016\/j.ijpharm.2019.118796\">https:\/\/doi.org\/10.1016\/j.ijpharm.2019.118796<\/a>]<\/li>\n\n\n\n<li>Nicolas Garraud, Rohan Dhavalikar<sup>G<\/sup>, Mythreyi Unni<sup>G<\/sup>, Shehaab Savliwala<sup>G<\/sup>, David P. Arnold, and <strong><u>Carlos Rinaldi<\/u><\/strong>, \u201cBenchtop magnetic particle relaxometer for detection, characterization, and analysis of magnetic nanoparticles.\u201d <em>Physics in Medicine and Biology<\/em>, <strong>63<\/strong>:175016, 2018. [<a href=\"http:\/\/doi.org\/10.1088\/1361-6560\/aad97d\">http:\/\/doi.org\/10.1088\/1361-6560\/aad97d<\/a>]<\/li>\n\n\n\n<li>Zhi Wei Tay, Prashant Chandrasekharan, Andreina Chiu-Lam<sup>G<\/sup>, Daniel Hensley, Rohan Dhavalikar<sup>G<\/sup>, Xinyi Zhou, Elaine Yu, Patrick Goodwill, Bo Zheng, <strong><u>Carlos Rinaldi<\/u><\/strong>, Steven M. Conolly, \u201cMagnetic Particle Imaging Guided Heating In Vivo using Gradient Fields For Arbitrary Localization of Thermal Therapy.\u201d <em>ACS Nano, <\/em><strong>12<\/strong>(4):3699-3713, 2018. [<a href=\"http:\/\/doi.org\/10.1021\/acsnano.8b00893\">http:\/\/doi.org\/10.1021\/acsnano.8b00893<\/a>]<\/li>\n\n\n\n<li>Nicolas Garraud, Rohan Dhavalikar<sup>G<\/sup>, Lorena Maldonado-Camargo<sup>G<\/sup>, David P. Arnold, and <strong><u>Carlos Rinaldi<\/u><\/strong>, \u201cDesign and Validation of Magnetic Particle Spectrometer for Characterization of Magnetic Nanoparticle Relaxation Dynamics.\u201d <em>AIP Advances<\/em>, <strong>7<\/strong>:056730, 2017. [<a href=\"http:\/\/doi.org\/10.1063\/1.4978003\">http:\/\/doi.org\/10.1063\/1.4978003<\/a>]<\/li>\n\n\n\n<li>Daniel Hensley, Zhi Wei Tay, Rohan Dhavalikar<sup>G<\/sup>, Bo Zheng, Patrick Goodwill, <strong>Carlos Rinaldi<\/strong>, Steven Conolly, \u201cCombining Magnetic Particle Imaging and magnetic fluid hyperthermia in a theranostic platform.\u201d <em>Physics in Medicine and Biology<\/em>, <strong>62<\/strong>(9):3483, 2017. [<a href=\"http:\/\/doi.org\/10.1088\/1361-6560\/aa5601\">http:\/\/doi.org\/10.1088\/1361-6560\/aa5601<\/a>]<\/li>\n\n\n\n<li>Mythreyi Unni<sup>G<\/sup>, Amanda Uhl, Shehaab Savliwala<sup>G<\/sup>, Benjamin Savitzky, Rohan Dhavalikar<sup>G<\/sup>, Nicolas Garraud, David Arnold, Lena Kourkoutis, Jennifer Andrew, and <strong><u>Carlos Rinaldi<\/u><\/strong>, \u201cThermal decomposition synthesis of iron oxide nanoparticles with diminished magnetic dead layer by controlled addition of oxygen.\u201d <em>ACS Nano<\/em>, <strong>11<\/strong>(2):2284-2303, 2017. [<a href=\"http:\/\/doi.org\/10.1021\/acsnano.7b00609\">http:\/\/doi.org\/10.1021\/acsnano.7b00609<\/a>]<\/li>\n\n\n\n<li>Rohan Dhavalikar<sup>G<\/sup> and <strong><u>Carlos Rinaldi<\/u><\/strong>, \u201cTheoretical Predictions for the Spatial Distribution of Magnetic Nanoparticle Heating in Magnetic Particle Imaging Field Gradients.\u201d <em>Journal of Magnetism and Magnetic Materials<\/em>, <strong>419<\/strong>:267-273, 2016. [<a href=\"http:\/\/doi.org\/10.1016\/j.jmmm.2016.06.038\">http:\/\/doi.org\/10.1016\/j.jmmm.2016.06.038<\/a>]<\/li>\n\n\n\n<li>Rohan Dhavalikar<sup>G<\/sup>, Lorena P. Maldonado-Camargo<sup>G<\/sup>, Daniel Hensley, Patrick S. Goodwill, Steven M. Conolly, and <strong><u>Carlos Rinaldi<\/u><\/strong>, \u201cFinite magnetic relaxation in X-Space magnetic particle imaging: Comparison of measurements and ferrohydrodynamic modeling.\u201d <em>Journal of Physics D<\/em>, <strong>49<\/strong>(30):305002, 2016. [<a href=\"http:\/\/doi.org\/10.1088\/0022-3727\/49\/30\/305002\">http:\/\/doi.org\/10.1088\/0022-3727\/49\/30\/305002<\/a>]<\/li>\n\n\n\n<li>Rohan Dhavalikar<sup>G<\/sup>, Nicolas Garraud, and <strong><u>Carlos Rinaldi<\/u><\/strong>, \u201cFerrohydrodynamic modeling of magnetic nanoparticle harmonic spectra for magnetic particle imaging.\u201d <em>Journal of Applied Physics<\/em>, <strong>118<\/strong>:173906, 2015. [<a href=\"http:\/\/doi.org\/10.1063\/1.4935158\">http:\/\/doi.org\/10.1063\/1.4935158<\/a>, PMID: 26576063]<\/li>\n\n\n\n<li>Rohan Dhavalikar<sup>G<\/sup> and <strong><u>Carlos Rinaldi<\/u><\/strong>, \u201cOn the effect of finite magnetic relaxation on the magnetic particle imaging performance of magnetic nanoparticles.\u201d <em>Journal of Applied Physics<\/em>, <strong>115<\/strong>:074308, 2014. [<a href=\"http:\/\/doi.org\/10.1063\/1.4866680\">http:\/\/doi.org\/10.1063\/1.4866680<\/a>]<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Magnetic particle imaging (MPI) is an emerging molecular imaging modality that enables non-invasive, tomographic, unambiguous, sensitive, and quantitative imaging of the distribution of superparamagnetic iron oxide nanoparticles (SPIONs) in a living subject. MPI signal is not attenuated by tissue and arises solely from exogenous SPIONs that are biocompatible and biodegradable. While MPI is relatively new, [&hellip;]<\/p>\n","protected":false},"author":468,"featured_media":0,"parent":72,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/page-section-nav.php","meta":{"_acf_changed":false,"inline_featured_image":false,"featured_post":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1339","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/pages\/1339","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/users\/468"}],"replies":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/comments?post=1339"}],"version-history":[{"count":1,"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/pages\/1339\/revisions"}],"predecessor-version":[{"id":1341,"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/pages\/1339\/revisions\/1341"}],"up":[{"embeddable":true,"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/pages\/72"}],"wp:attachment":[{"href":"https:\/\/faculty.eng.ufl.edu\/rinaldi\/wp-json\/wp\/v2\/media?parent=1339"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}